The Bewildering Antitubercular Action of Pyrazinamide
نویسندگان
چکیده
منابع مشابه
Pantothenate and pantetheine antagonize the antitubercular activity of pyrazinamide.
Pyrazinamide (PZA) is a first-line tuberculosis drug that inhibits the growth of Mycobacterium tuberculosis via an as yet undefined mechanism. An M. tuberculosis laboratory strain that was auxotrophic for pantothenate was found to be insensitive to PZA and to the active form, pyrazinoic acid (POA). To determine whether this phenotype was strain or condition specific, the effect of pantothenate ...
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ژورنال
عنوان ژورنال: Microbiology and Molecular Biology Reviews
سال: 2020
ISSN: 1092-2172,1098-5557
DOI: 10.1128/mmbr.00070-19